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CORRECTION article

Front. Neurosci., 28 May 2021
Sec. Neuroendocrine Science
Volume 15 - 2021 | https://doi.org/10.3389/fnins.2021.694239
This article is part of the Research Topic Brain-Liver Axis and Glutamate Homeostasis View all 8 articles

Corrigendum: Cognitive Impairment After Resolution of Hepatic Encephalopathy: A Systematic Review and Meta-Analysis

This article is a correction to:

  1. Cognitive Impairment After Resolution of Hepatic Encephalopathy: A Systematic Review and Meta-Analysis

    1. Read original article
\n scar Lpez-Franco&#x;Óscar López-Franco1†Jean-Pascal Morin&#x;Jean-Pascal Morin2†Albertina Corts-SolAlbertina Cortés-Sol3Tania Molina-JimnezTania Molina-Jiménez4Diana I. Del MoralDiana I. Del Moral5Mnica Flores-MuozMónica Flores-Muñoz1Gabriel Roldn-RoldnGabriel Roldán-Roldán2Claudia Jurez-PortillaClaudia Juárez-Portilla6Rossana C. Zepeda Rossana C. Zepeda6*
  • 1Laboratorio de Medicina Traslacional, Instituto de Ciencias de la Salud, Universidad Veracruzana, Xalapa, Mexico
  • 2Laboratorio de Neurobiología de la Conducta, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de Mexico, Ciudad de Mexico, Mexico
  • 3Facultad de Biología-Xalapa, Universidad Veracruzana, Xalapa, Mexico
  • 4Instituto Interdisciplinario de Investigaciones de la Universidad de Xalapa, Xalapa, Mexico
  • 5Programa de Doctorado en Ciencias Biomédicas, Universidad Veracruzana, Xalapa, Mexico
  • 6Laboratorio de Biomedicina Integral y Salud, Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa, Mexico

A Corrigendum on
Cognitive Impairment After Resolution of Hepatic Encephalopathy: A Systematic Review and Meta-Analysis

by López-Franco, Ó., Morin, J-P., Cortés-Sol, A., Molina-Jiménez, T., Del Moral, D. I., Flores-Muñoz, M., et al. (2021). Front. Neurosci. 15:579263. doi: 10.3389/fnins.2021.579263

In the original article, there was an error in the value of Std. Mean Difference stated in the last sentence of the Abstract.

A correction has been made to Abstract section. The corrected Abstract is shown below.

Hepatic encephalopathy (HE) is one of the most disabling metabolic diseases. It consists of a complication of liver disease through the action of neurotoxins, such as excessive production of ammonia from liver, resulting in impaired brain function. Its prevalence and incidence are not well known, although it has been established that up to 40% of cirrhotic patients may develop HE. Patients with HE episodes display a wide range of neurological disturbances, from subclinical alterations to coma. Recent evidence suggests that the resolution of hepatic encephalopathy does not fully restore cognitive functioning in cirrhotic patients. Therefore, the aim of this review was to evaluate the evidence supporting the presence of lingering cognitive deficits in patients with a history of HE compared to patients without HE history and how liver transplant affects such outcome in these patients. We performed two distinct meta-analysis of continuous outcomes. In both cases the results were pooled using random-effects models. Our results indicate that cirrhotic patients with a history of HE show clear cognitive deficits compared to control cirrhotic patients (Std. Mean Difference (in SDs) = −0.72 [CI 95%: −0.94, −0.50]) and that these differences are not fully restored after liver transplant (Std. Mean Difference (in SDs) = −0.48 [CI 95%: −0.77, −0.19]).

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Keywords: learning, cognition, liver disease, cirrhosis, impairment, psychometric test, liver transplant

Citation: López-Franco Ó, Morin J-P, Cortés-Sol A, Molina-Jiménez T, Del Moral DI, Flores-Muñoz M, Roldán-Roldán G, Juárez-Portilla C and Zepeda RC (2021) Corrigendum: Cognitive Impairment After Resolution of Hepatic Encephalopathy: A Systematic Review and Meta-Analysis. Front. Neurosci. 15:694239. doi: 10.3389/fnins.2021.694239

Received: 12 April 2021; Accepted: 30 April 2021;
Published: 28 May 2021.

Edited and reviewed by: Mustapha Najimi, Catholic University of Louvain, Belgium

Copyright © 2021 López-Franco, Morin, Cortés-Sol, Molina-Jiménez, Del Moral, Flores-Muñoz, Roldán-Roldán, Juárez-Portilla and Zepeda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Rossana C. Zepeda, rzepeda@uv.mx

†These authors have contributed equally to this work and share first authorship

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