This article is a correction to:
Digenic Variants in the TTN and TRAPPC11 Genes Co-segregating With a Limb-Girdle Muscular Dystrophy in a Han Chinese Family
Qian Chen
Wen Zheng
Hongbo Xu
Yan Yang
Zhi Song
Lamei Yuan
Hao Deng- 1Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, China
- 2Department of Pathology, The Third Xiangya Hospital, Central South University, Changsha, China
- 3Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China
- 4Disease Genome Research Center, Central South University, Changsha, China
A Corrigendum on
Digenic Variants in the TTN and TRAPPC11 Genes Co-segregating With a Limb-Girdle Muscular Dystrophy in a Han Chinese Family
by Chen, Q., Zheng, W., Xu, H., Yang, Y., Song, Z., Yuan, L., et al. (2021). Front. Neurosci. 15:601757. doi: 10.3389/fnins.2021.601757
In the original article, there was an error in Conclusion as published.
“TTN c.3092C greater than G (p.Leu6494Arg)” should be changed to “TTN c.19481T greater than G (p.Leu6494Arg)”. The corrected section appears below.
In summary, digenic variants TTN c.19481T greater than G (p.Leu6494Arg) and TRAPPC11 c.3092C greater than G (p.Pro1031Arg) were observed in a LGMD family and co-segregated with the disease phenotype, which may be responsible for the LGMD phenotype. However, our study cannot exclude the missed inspection such as complex rearrangement, gross deletion and gross duplication, as well as deep pathogenic point variants in introns involved in monogenic LGMD, presenting autosomal dominant or pseudo-dominant phenomenon. Our study provides a possibility of a digenic mechanism in unsolved families with muscular dystrophies.
In addition, there was a mistake in the caption for Figure 1 as published. Within the description for Figure 1B, “TTN c.3092C greater than G (p.Leu6494Arg)” should be changed to “TTN c.19481T greater than G (p.Leu6494Arg)”. The corrected caption appears below.
(Figure 1). Pedigree and genetic data of the individuals in this study. (A) Pedigree of a Han Chinese three-generation family with LGMD. Arrow symbolizes proband; N, normal allele; V1, TTN c.19481T greater than G variant; V2, TRAPPC11 c.3092C greater than G variant. (B) The sequencing diagram of heterozygous TTN c.19481T greater than G (p.Leu6494Arg) variant. (C) The sequencing diagram of heterozygous TRAPPC11 c.3092C greater than G (p.Pro1031Arg) variant. (D) Sequence of normal control in the TTN gene. (E) Sequence of normal control in the TRAPPC11 gene. LGMD, limb-girdle muscular dystrophies; TTN, the titin gene; TRAPPC11, the trafficking protein particle complex 11 gene.
The authors apologize for these errors and state that they do not change the scientific conclusions of the article in any way. The original article has been updated.
Keywords: limb-girdle muscular dystrophies, digenic variants, the TTN gene, the TRAPPC11 gene, exome sequencing
Citation: Chen Q, Zheng W, Xu H, Yang Y, Song Z, Yuan L and Deng H (2021) Corrigendum: Digenic Variants in the TTN and TRAPPC11 Genes Co-segregating With a Limb-Girdle Muscular Dystrophy in a Han Chinese Family. Front. Neurosci. 15:678618. doi: 10.3389/fnins.2021.678618
Received: 10 March 2021; Accepted: 12 March 2021;
Published: 21 April 2021.
Edited and reviewed by: Marco Savarese, University of Helsinki, Finland
Copyright © 2021 Chen, Zheng, Xu, Yang, Song, Yuan and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Lamei Yuan, yuanlamei229@163.com; Hao Deng, hdeng008@yahoo.com