AUTHOR=Bainomugisa Charlotte K. , Sutherland Heidi G. , Parker Richard , Mcrae Allan F. , Haupt Larisa M. , Griffiths Lyn R. , Heath Andrew , Nelson Elliot C. , Wright Margaret J. , Hickie Ian B. , Martin Nicholas G. , Nyholt Dale R. , Mehta Divya TITLE=Using Monozygotic Twins to Dissect Common Genes in Posttraumatic Stress Disorder and Migraine JOURNAL=Frontiers in Neuroscience VOLUME=15 YEAR=2021 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.678350 DOI=10.3389/fnins.2021.678350 ISSN=1662-453X ABSTRACT=
Epigenetic mechanisms have been associated with genes involved in Posttraumatic stress disorder (PTSD). PTSD often co-occurs with other health conditions such as depression, cardiovascular disorder and respiratory illnesses. PTSD and migraine have previously been reported to be symptomatically positively correlated with each other, but little is known about the genes involved. The aim of this study was to understand the comorbidity between PTSD and migraine using a monozygotic twin disease discordant study design in six pairs of monozygotic twins discordant for PTSD and 15 pairs of monozygotic twins discordant for migraine. DNA from peripheral blood was run on Illumina EPIC arrays and analyzed. Multiple testing correction was performed using the Bonferroni method and 10% false discovery rate (FDR). We validated 11 candidate genes previously associated with PTSD including