AUTHOR=Toledo Juan P. , Fernández-Pérez Eduardo J. , Ferreira Ildete L. , Marinho Daniela , Riffo-Lepe Nicolas O. , Pineda-Cuevas Benjamin N. , Pinochet-Pino Luis F. , Burgos Carlos F. , Rego A. Cristina , Aguayo Luis G. TITLE=Boldine Attenuates Synaptic Failure and Mitochondrial Deregulation in Cellular Models of Alzheimer’s Disease JOURNAL=Frontiers in Neuroscience VOLUME=15 YEAR=2021 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.617821 DOI=10.3389/fnins.2021.617821 ISSN=1662-453X ABSTRACT=
Alzheimer’s disease (AD) is the most common cause of senile dementia worldwide, characterized by both cognitive and behavioral deficits. Amyloid beta peptide (Aβ) oligomers (AβO) have been found to be responsible for several pathological mechanisms during the development of AD, including altered cellular homeostasis and synaptic function, inevitably leading to cell death. Such AβO deleterious effects provide a way for identifying new molecules with potential anti-AD properties. Available treatments minimally improve AD symptoms and do not extensively target intracellular pathways affected by AβO. Naturally-derived compounds have been proposed as potential modifiers of Aβ-induced neurodysfunction and cytotoxicity based on their availability and chemical diversity. Thus, the aim of this study was to evaluate boldine, an alkaloid derived from the bark and leaves of the Chilean tree