AUTHOR=Chang Yan , Li Can , Yang Hui , Wu Yue , Xu Baixuan , Zhang Jinming , Wang Ruimin 

TITLE=18F-Florbetaben Amyloid PET Imaging: A Chinese Study in Cognitive Normal Controls, Mild Cognitive Impairment, and Alzheimer’s Disease Patients

JOURNAL=Frontiers in Neuroscience

VOLUME=14

YEAR=2020

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2020.00745

DOI=10.3389/fnins.2020.00745

ISSN=1662-453X

ABSTRACT=<sec><title>Objective</title><p>To evaluate amyloid-β deposition with <sup>18</sup>F-florbetaben (FBB) PET imaging against <sup>11</sup>C-PIB PET in cognitive normal controls (NC), mild cognitive impairment (MCI), and Alzheimer’s disease (AD) patients.</p></sec><sec><title>Methods</title><p>We recruited 45 subjects (15 in each group of NC, MCI, and mild/moderate AD) who had undergone dynamic <sup>18</sup>F-FBB amyloid PET imaging. For comparison study, 17 participants, including six NC, five MCI, and six AD patients, also underwent <sup>11</sup>C-PIB PET imaging on separate days. Standardized uptake value ratios (SUVR) were calculated using the cerebellar cortex as the reference region with regions of interest (ROI) manually defined on co-registered CT. Quantitative analysis of mean cortical uptake was calculated using global SUVR. Spearman correlation analysis between MMSE scores and SUVR of 18F-FBB and 11C-PIB images were calculated.</p></sec><sec><title>Results</title><p>One (7%) of the 15 NC participants, nine (60%) of 15 MCI patients, and 12 (80%) of 15 AD patients had amyloid-positive lesions on <sup>18</sup>F-FBB PET images. In AD patients, global SUVR was significantly higher than those of MCI patients (1.73 ± 0.62 vs. 1.55 ± 0.11, <italic>P</italic> &lt; 0.001) and NC subjects (1.73 ± 0.62 vs. 1.13 ± 0.43, <italic>P</italic> &lt; 0.001). In the comparison study, one NC participant, five MCI patients, and five AD patients had amyloid-positive lesions on <sup>11</sup>C-PIB PET images. There was a significant linear correlation (<italic>r</italic><sup>2</sup> = 0.81, <italic>P</italic> &lt; 0.001) between <sup>18</sup>F-FBB and PIB global SUVR values. MMSE scores had negative correlations with SUVR on <sup>11</sup>C-PIB PET (<italic>r</italic><sub>1</sub> = –0.650, <italic>P</italic> = 0.005) or SUVR on <sup>18</sup>F-FBB PET (<italic>r</italic><sub>2</sub> = –0.754, <italic>P</italic> &lt; 0.0001).</p></sec><sec><title>Conclusion</title><p>Our study suggests that <sup>18</sup>F-FBB is a useful tracer for the evaluation of amyloid-β deposition in vivo and that global SUVR of <sup>18</sup>F-FBB PET might be a reliable tool in the diagnosis of AD.</p></sec>