AUTHOR=Seegobin Steven P. , Heaton George R. , Liang Dongxiao , Choi Insup , Blanca Ramirez Marian , Tang Beisha , Yue Zhenyu 

TITLE=Progress in LRRK2-Associated Parkinson’s Disease Animal Models

JOURNAL=Frontiers in Neuroscience

VOLUME=14

YEAR=2020

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2020.00674

DOI=10.3389/fnins.2020.00674

ISSN=1662-453X

ABSTRACT=<p>Mutations in the leucine-rich repeat kinase 2 (<italic>LRRK2</italic>) gene are the most frequent cause of familial Parkinson’s disease (PD). Several genetic manipulations of the <italic>LRRK2</italic> gene have been developed in animal models such as rodents, <italic>Drosophila</italic>, <italic>Caenorhabditis elegans</italic>, and zebrafish. These models can help us further understand the biological function and derive potential pathological mechanisms for LRRK2. Here we discuss common phenotypic themes found in <italic>LRRK2</italic>-associated PD animal models, highlight several issues that should be addressed in future models, and discuss emerging areas to guide their future development.</p>