AUTHOR=Manion John , Waller Matthew A. , Clark Teleri , Massingham Joshua N. , Neely G. Gregory TITLE=Developing Modern Pain Therapies JOURNAL=Frontiers in Neuroscience VOLUME=13 YEAR=2019 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2019.01370 DOI=10.3389/fnins.2019.01370 ISSN=1662-453X ABSTRACT=

Chronic pain afflicts as much as 50% of the population at any given time but our methods to address pain remain limited, ineffective and addictive. In order to develop new therapies an understanding of the mechanisms of painful sensitization is essential. We discuss here recent progress in the understanding of mechanisms underlying pain, and how these mechanisms are being targeted to produce modern, specific therapies for pain. Finally, we make recommendations for the next generation of targeted, effective, and safe pain therapies.