AUTHOR=Galieva Luisa R. , James Victoria , Mukhamedshina Yana O. , Rizvanov Albert A. 

TITLE=Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders

JOURNAL=Frontiers in Neuroscience

VOLUME=13

YEAR=2019

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2019.00163

DOI=10.3389/fnins.2019.00163

ISSN=1662-453X

ABSTRACT=<p>The use of extracellular vesicles (EVs) as cell free therapy is a promising approach to stimulate tissue regeneration including that of the nervous system. EVs transfer bioactive proteins and lipids, RNA and microRNAs, which play a relevant role in EV-mediated intercellular communication. The immunomodulatory, anti-inflammatory, and neuroprotective effects of mesenchymal stem cells-derived EVs have been well studied, knowledge of this paracrine mechanism and the availability of these cells, positions mesenchymal stem cells as a potential source of EVs for cell free therapy for a variety of regenerative and nervous system disorders. In this review, we focus on the immunomodulatory and neuroprotective effects of stem cells-derived EVs within <italic>in vitro</italic> and <italic>in vivo</italic> models of nerve disorders.</p>