AUTHOR=Liu Jinping , Chang Lirong , Song Yizhi , Li Hui , Wu Yan 

TITLE=The Role of NMDA Receptors in Alzheimer’s Disease

JOURNAL=Frontiers in Neuroscience

VOLUME=13

YEAR=2019

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2019.00043

DOI=10.3389/fnins.2019.00043

ISSN=1662-453X

ABSTRACT=<p>In Alzheimer’s disease (AD), early synaptic dysfunction is associated with the increased oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression and spine elimination. Memantine, low-affinity NMDAR channel blocker, has been used in the treatment of moderate to severe AD. However, clear evidence is still deficient in demonstrating the underlying mechanisms and a relationship between NMDARs dysfunction and AD. This review focuses on not only changes in expression of different NMDAR subunits, but also some unconventional modes of NMDAR action.</p>