AUTHOR=Zhao Xiu-Yun , Lu Mei-Hong , Yuan De-Juan , Xu De-En , Yao Pei-Pei , Ji Wen-Li , Chen Hong , Liu Wen-Long , Yan Chen-Xiao , Xia Yi-Yuan , Li Shao , Tao Jin , Ma Quan-Hong 

TITLE=Mitochondrial Dysfunction in Neural Injury

JOURNAL=Frontiers in Neuroscience

VOLUME=13

YEAR=2019

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2019.00030

DOI=10.3389/fnins.2019.00030

ISSN=1662-453X

ABSTRACT=<p>Mitochondria are the double membrane organelles providing most of the energy for cells. In addition, mitochondria also play essential roles in various cellular biological processes such as calcium signaling, apoptosis, ROS generation, cell growth, and cell cycle. Mitochondrial dysfunction is observed in various neurological disorders which harbor acute and chronic neural injury such as neurodegenerative diseases and ischemia, hypoxia-induced brain injury. In this review, we describe how mitochondrial dysfunction contributes to the pathogenesis of neurological disorders which manifest chronic or acute neural injury.</p>