AUTHOR=Cellai Lucrezia , Carvalho Kevin , Faivre Emilie , Deleau Aude , Vieau Didier , Buée Luc , Blum David , Mériaux Céline , Gomez-Murcia Victoria 

TITLE=The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease

JOURNAL=Frontiers in Neuroscience

VOLUME=12

YEAR=2018

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2018.00520

DOI=10.3389/fnins.2018.00520

ISSN=1662-453X

ABSTRACT=<p>Alzheimer’s disease (AD) is the most common neurodegenerative disorder in elderly people. AD is characterized by a progressive cognitive decline and it is neuropathologically defined by two hallmarks: extracellular deposits of aggregated β-amyloid (Aβ) peptides and intraneuronal fibrillar aggregates of hyper- and abnormally phosphorylated Tau proteins. AD results from multiple genetic and environmental risk factors. Epidemiological studies reported beneficial effects of caffeine, a non-selective adenosine receptors antagonist. In the present review, we discuss the impact of caffeine and of adenosinergic system modulation on AD, in terms of pathology and therapeutics.</p>