AUTHOR=Grundeis Felicitas , Brand Cristin , Kumar Saurabh , Rullmann Michael , Mehnert Jan , Pleger Burkhard 

TITLE=Non-invasive Prefrontal/Frontal Brain Stimulation Is Not Effective in Modulating Food Reappraisal Abilities or Calorie Consumption in Obese Females

JOURNAL=Frontiers in Neuroscience

VOLUME=11

YEAR=2017

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2017.00334

DOI=10.3389/fnins.2017.00334

ISSN=1662-453X

ABSTRACT=<p><bold>Background/Objectives:</bold> Previous studies suggest that non-invasive transcranial direct current stimulation (tDCS) applied to the prefrontal cortex modulates food choices and calorie intake in obese humans.</p><p><bold>Participants/Methods:</bold> In the present fully randomized, placebo-controlled, within-subject and double-blinded study, we applied single sessions of anodal, cathodal, and sham tDCS to the left dorsolateral prefrontal cortex (DLPFC) and contralateral frontal operculum in 25 hungry obese women and investigated possible influences on food reappraisal abilities as well as calorie intake. We hypothesized that tDCS, (i) improves the ability to regulate the desire for visually presented foods and, (ii) reduces their consumption.</p><p><bold>Results:</bold> We could not confirm an effect of anodal or cathodal tDCS, neither on the ability to modulate the desire for visually presented foods, nor on calorie consumption.</p><p><bold>Conclusions:</bold> The present findings do not support the notion of prefrontal/frontal tDCS as a promising treatment option for obesity.</p>