AUTHOR=Jones Ian L. , Russell Thomas L. , Farrow Karl , Fiscella Michele , Franke Felix , Müller Jan , Jäckel David , Hierlemann Andreas TITLE=A method for electrophysiological characterization of hamster retinal ganglion cells using a high-density CMOS microelectrode array JOURNAL=Frontiers in Neuroscience VOLUME=9 YEAR=2015 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2015.00360 DOI=10.3389/fnins.2015.00360 ISSN=1662-453X ABSTRACT=
Knowledge of neuronal cell types in the mammalian retina is important for the understanding of human retinal disease and the advancement of sight-restoring technology, such as retinal prosthetic devices. A somewhat less utilized animal model for retinal research is the hamster, which has a visual system that is characterized by an area centralis and a wide visual field with a broad binocular component. The hamster retina is optimally suited for recording on the microelectrode array (MEA), because it intrinsically lies flat on the MEA surface and yields robust, large-amplitude signals. However, information in the literature about hamster retinal ganglion cell functional types is scarce. The goal of our work is to develop a method featuring a high-density (HD) complementary metal-oxide-semiconductor (CMOS) MEA technology along with a sequence of standardized visual stimuli in order to categorize ganglion cells in isolated Syrian Hamster (