AUTHOR=Spiers Jereme G. , Chen Hsiao-Jou Cortina , Sernia Conrad , Lavidis Nickolas A. 

TITLE=Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress

JOURNAL=Frontiers in Neuroscience

VOLUME=8

YEAR=2015

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2014.00456

DOI=10.3389/fnins.2014.00456

ISSN=1662-453X

ABSTRACT=<p>Glucocorticoids released from the adrenal gland in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis induce activity in the cellular reduction-oxidation (redox) system. The redox system is a ubiquitous chemical mechanism allowing the transfer of electrons between donor/acceptors and target molecules during oxidative phosphorylation while simultaneously maintaining the overall cellular environment in a reduced state. The objective of this review is to present an overview of the current literature discussing the link between HPA axis-derived glucocorticoids and increased oxidative stress, particularly focussing on the redox changes observed in the hippocampus following glucocorticoid exposure.</p>