AUTHOR=Liu Dawei , Johnson Hans J. , Long Jeffrey D. , Magnotta Vincent A. , Paulsen Jane S. 

TITLE=The power-proportion method for intracranial volume correction in volumetric imaging analysis

JOURNAL=Frontiers in Neuroscience

VOLUME=8

YEAR=2014

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2014.00356

DOI=10.3389/fnins.2014.00356

ISSN=1662-453X

ABSTRACT=<p>In volumetric brain imaging analysis, volumes of brain structures are typically assumed to be proportional or linearly related to intracranial volume (<italic>ICV</italic>). However, evidence abounds that many brain structures have power law relationships with <italic>ICV</italic>. To take this relationship into account in volumetric imaging analysis, we propose a power law based method—the power-proportion method—for <italic>ICV</italic> correction. The performance of the new method is demonstrated using data from the PREDICT-HD study.</p>