AUTHOR=Raucci Franca , Tiong Jean D., Wray Susan TITLE=P75 nerve growth factor receptors modulate development of GnRH neurons and olfactory ensheating cells JOURNAL=Frontiers in Neuroscience VOLUME=7 YEAR=2013 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2013.00262 DOI=10.3389/fnins.2013.00262 ISSN=1662-453X ABSTRACT=
Temporal and spatial localization of nerve growth factor receptor (p75NGFR) in the developing olfactory system and gonadotropin-releasing hormone-1 (GnRH) system was characterized and its role analyzed using p75NGFR null mice and nasal explants. Prenatally, p75NGFR was expressed by GnRH neurons and olfactory ensheathing cells (OECs). In p75NGFR null mice, no change in the number of GnRH cells was detected as compared to wild-type. However, in null mice, a shift in the distribution of GnRH neurons was found, with a small population of GnRH cells migrating further caudally toward the median eminence. Additionally, a reduction of both GAD67 positive olfactory axons and GFAP positive OEC fibers occurred. Acute administration of a p75NGFR blocker to GnRH cells maintained