AUTHOR=Bali Namrata , Morgan Todd E., Finch Caleb E.

TITLE=Pgrmc1: new roles in the microglial mediation of progesterone-antagonism of estradiol-dependent neurite sprouting and in microglial activation

JOURNAL=Frontiers in Neuroscience

VOLUME=7

YEAR=2013

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2013.00157

DOI=10.3389/fnins.2013.00157

ISSN=1662-453X

ABSTRACT=<p>Pgrmc1 (progesterone receptor membrane component 1) is a multifunctional 22 kDa protein with heme-binding and P450-activating capacity which was recognized under different names for roles in cell motility during neural development and in cancer, and apoptosis. Pgrmc1 expression in microglia was recently shown by the present authors to mediate estrogen-progesterone interactions during axonal sprouting and to mediate microglial activation itself. We also discuss other functions of Pgramc1 in the nervous system and its possible relationship to the 18 kDa sigma-2 receptor (S2R).</p>