AUTHOR=Tsou Ryan , Bence Kendra 

TITLE=Central Regulation of Metabolism by Protein Tyrosine Phosphatases

JOURNAL=Frontiers in Neuroscience

VOLUME=6

YEAR=2013

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2012.00192

DOI=10.3389/fnins.2012.00192

ISSN=1662-453X

ABSTRACT=<p>Protein tyrosine phosphatases (PTPs) are important regulators of intracellular signaling pathways via the dephosphorylation of phosphotyrosyl residues on various receptor and non-receptor substrates. The phosphorylation state of central nervous system (CNS) signaling components underlies the molecular mechanisms of a variety of physiological functions including the control of energy balance and glucose homeostasis. In this review, we summarize the current evidence implicating PTPs as central regulators of metabolism, specifically highlighting their interactions with the neuronal leptin and insulin signaling pathways. We discuss the role of a number of PTPs (PTP1B, SHP2, TCPTP, RPTPe, and PTEN), reviewing the findings from genetic mouse models and <italic>in vitro</italic> studies which highlight these phosphatases as key central regulators of energy homeostasis.</p>