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BRIEF RESEARCH REPORT article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1566228
Exploring Tau-C, Tau-A and C1M as Biomarkers for Parkinson's Disease
Provisionally accepted- 1Research fellow, København Nv, Denmark
- 2Directory of endocrinology, København Nv, Denmark
- 3CEO, København Nv, Denmark
- 4Scientific director -Immunoscience, København Nv, Denmark
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Tau has shown to be associated with neurodegenerative diseases. In this exploratory study, we investigated the utility of blood-based biomarkers measuring Tau-C, Tau-A and C1M in Parkinson's disease (PD) to explore their potential as diagnostic biomarkers in two independent cohorts (TAU-C, TAU-A). We found them to discriminate between healthy donors and PD individuals (all p<0.001), with Tau-C showing the best diagnostic discrepancy (AUROC = 0.97). Therefore, Tau-C, Tau-A and C1M may be biomarkers for PD diagnosis.
Keywords: biomarker, Parkinson's disease, Tau-C, Tau-A, C1M
Received: 24 Jan 2025; Accepted: 08 Apr 2025.
Copyright: © 2025 Benmarce, Henriksen, Karsdal and Holm Nielsen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Meryem Benmarce, Research fellow, København Nv, Denmark
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.