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ORIGINAL RESEARCH article
Front. Neurol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1563041
Frequency, Risk Factors, and Quality of Life Impact of Sleep Problems in Egyptian Patients with Multiple Sclerosis
Provisionally accepted
Eman M Khedr1,2*
Gellan Ahmed1
Shady Mohamed Safwat Mohamed Hassan1
Mohamed Nageh Foly3Motez Mahmoud Attia3
Nourelhoda A Haridy1- 1Department of Neurology and Psychiatry, Faculty of Medicine, Assiut University, Assiut, Asyut, Egypt
- 2Department of Neuropsychiatry, Faculty of Medicine, Aswan University, Aswan, Aswan, Egypt
- 3Intern doctor, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt
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Background: Sleep problems impact over 65% of patients with multiple sclerosis (MS), a prevalence significantly greater than that observed in the general population. This study aimed to assess the frequent and risk-associated factors of sleep problems in a large MS cohort and evaluate their impact on quality of life (QoL).The study included 103 participants with MS across different disease stages and 62 healthy controls. Assessment tools included the Expanded Disability Status Scale (EDSS), Pittsburgh Sleep Quality Index (PSQI), depression and fatigue scales, 9-Hole Peg Test, 25-foot walk test, cognitive function assessments, and QoL measures.Results: Sleep problems were significantly more frequent in MS patients (68.9%) than in controls (30.6%). PSQI scores showed positive correlations with the number of MS relapses across the course of disease duration, walking impairment, fatigue and depression scores. Sleep problems were determined to adversely affect various domains of quality of life.Our findings demonstrate that sleep Problems are remarkably common among patients with MS. Patients experiencing poor sleep quality are typically associated with higher levels of fatigue, depression, greater difficulty with mobility, and more frequent disease relapses. These sleep problems significantly impaired the overall QoL in MS patients. As a primary goal, the abstract should render the general significance and conceptual advance of the work accessible to a broad readership.
Keywords: Multiple Sclerosis, sleep quality, Quality of Life, Fatigue, Pittsburgh Sleep Quality Index
Received: 18 Jan 2025; Accepted: 07 Apr 2025.
Copyright: © 2025 Khedr, Ahmed, Hassan, Foly, Attia and Haridy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Eman M Khedr, Department of Neurology and Psychiatry, Faculty of Medicine, Assiut University, Assiut, Asyut, Egypt
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.