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CASE REPORT article

Front. Neurol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1557385
This article is part of the Research Topic Advancements in Meningioma Management: From Imaging Techniques to Personalized Medicine Approaches View all 3 articles

Primary Scalp-Intracranial Rosai-Dorfman Disease (RDD): Diagnosis and Treatment of a Rare Case with Literature Review

Provisionally accepted
Qin Zhenwei Qin Zhenwei 1*Beiyan Tang Beiyan Tang 1,2Chen Ding Chen Ding 3*Qu Huixia Qu Huixia 4*Zhao Xianjun Zhao Xianjun 1*Yawen Pan Yawen Pan 1,5*
  • 1 Lanzhou University Second Hospital, Lanzhou, Gansu Province, China
  • 2 Lanzhou University, Lanzhou, China
  • 3 Gansu Province Hospital Rehabilitation Center, Lanzhou, Gansu Province, China
  • 4 The First People's Hospital of Lanzhou New District, lanzhou, China
  • 5 Key Laboratory of Neurology of Gansu Province, Lanzhou, Gansu Province, China

The final, formatted version of the article will be published soon.

    Dorfman-Destombes disease (RDD) is a rare histiocytic proliferative disorder, with primary scalp and intracranial involvement being particularly uncommon. The imaging features and clinical manifestations of RDD often overlap with other intracranial lesions, such as meningiomas, leading to misdiagnosis. This study presents a case of primary scalp and intracranial RDD, with a comprehensive analysis of its imaging, pathological, and intraoperative findings, alongside a review of the literature on central nervous system (CNS) RDD and its diagnostic and therapeutic advancements. Preoperative CT and MRI scans clearly depicted characteristic changes in the scalp and intracranial lesions. However, the preoperative assessment failed to fully recognize abnormalities in the skull base, leading to an incomplete initial understanding. During surgery, the dura mater and obstructed superior sagittal sinus were resected extensively, and the pathology confirmed RDD. Postoperative recovery was smooth, and no recurrence was observed during follow-up. This case emphasizes the importance of detailed imaging in the diagnosis and treatment of RDD, combining preoperative evaluation with intraoperative observations to reduce the risk of misdiagnosis and recurrence. Furthermore, the exploration of individualized treatment strategies and targeted therapies plays a crucial role in managing complex cases. This study offers valuable experience for the diagnosis and treatment of similar rare cases.

    Keywords: Rosai-Dorfman-Destombes Disease, Histiocytic proliferation, Imaging evaluation, Neuronavigation, surgical treatment

    Received: 08 Jan 2025; Accepted: 03 Feb 2025.

    Copyright: © 2025 Zhenwei, Tang, Ding, Huixia, Xianjun and Pan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qin Zhenwei, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu Province, China
    Chen Ding, Gansu Province Hospital Rehabilitation Center, Lanzhou, 730000, Gansu Province, China
    Qu Huixia, The First People's Hospital of Lanzhou New District, lanzhou, China
    Zhao Xianjun, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu Province, China
    Yawen Pan, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu Province, China

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