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ORIGINAL RESEARCH article
Front. Neurol.
Sec. Dementia and Neurodegenerative Diseases
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1555587
This article is part of the Research Topic Blood, Cerebrospinal Fluid, and Vascular Biomarkers for Dementia View all 14 articles
Hyperuricemia Reduces the Risk of MCI but Not Dementia: A Cross-Sectional Study in Liuyang
Provisionally accepted- 1 Department of Neurology, The First Affiliated Hospital, Jinan University, Guangzhou, China
- 2 Department of Neurology, Liuyang Jili Hospital, Changsha, China
- 3 Department of Neurology, Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, China
- 4 Department of Neurology, Haikou Hospital Affiliated to Xiangya School of Medicine, Central South University, Haikou, Hainan Province, China
- 5 Department of Hematology, Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China., Zhanjiang, China
- 6 Department of Anesthesiology, Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, China
- 7 Liuyang Jili Hospital, Changsha, China
Background: Cognitive impairments, including mild cognitive impairment (MCI) and dementia, significantly affect patients' daily functions and quality of life, contributing to a substantial societal and economic burden. The role of uric acid in cognitive function is controversial, with some studies suggesting protective effects, while others indicate increased risk of cognitive decline. Methods: A total of 1,098 participants with an average age of 69 years were included in the study. Cognitive function was assessed using the Mini-Mental State Examination.Hyperuricemia was defined as blood uric acid concentrations >420 μmol/L. Logistic regression and restricted cubic spline analysis were performed to assess the association between hyperuricemia and cognitive impairment, including MCI and dementia.Results: Hyperuricemia was associated with a lower risk of cognitive impairment (OR=0.51, 95% CI=0.31-0.80) and MCI (OR=0.39, 95% CI=0.21-0.69), particularly in individuals younger than 70 years, males, and those without hypertension or diabetes.No significant association was found between hyperuricemia and dementia (OR=0.94, 95% CI=0.44-1.89). There is no evidence of a non-linear relationship between hyperuricemia and cognitive impairment.Conclusions: Hyperuricemia appears to have a protective effect on cognitive function, particularly in reducing the risk of MCI, but not dementia, in specific populations.
Keywords: Hyperuricemia, cognitive impairment, Mild Cognitive Impairment, Dementia, Cross-sectional study
Received: 05 Jan 2025; Accepted: 26 Feb 2025.
Copyright: © 2025 He, Zhu, Bei, Xiang, Xi, Meng and Bei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Heng Meng, Department of Neurology, The First Affiliated Hospital, Jinan University, Guangzhou, China
Yuzhang Bei, Liuyang Jili Hospital, Changsha, China
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