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ORIGINAL RESEARCH article
Front. Neurol.
Sec. Applied Neuroimaging
Volume 16 - 2025 |
doi: 10.3389/fneur.2025.1550014
This article is part of the Research Topic Bridging Gaps in Neuroimaging: Enhancing Diagnostic Precision in Cerebrovascular Disease View all 12 articles
Study on the Correlation between Carotid Plaque Calcification Types and Acute Ischemic Stroke
Provisionally accepted- Lianyungang Clinical Medical College, Nanjing Medical University, Lianyungang, China
Computed tomography angiography (CTA) was used to explore the correlation between the calcification types of carotid plaques and ipsilateral acute ischemic stroke. This could provide new insights into the clinical evaluation and treatment of ischemic stroke. This study obtained information on patients undergoing head and neck CTA examinations at the First People's Hospital of Lianyungang between September 2022 and August 2023 to investigate the clinical differences in baseline data between the acute ischemic stroke and control groups. Patients meeting the inclusion and exclusion criteria were classified into 1 to 6 groups according to their plaque calcification characteristics. The correlation between calcified plaque type and ipsilateral acute ischemic anterior circulation stroke was analyzed using paired sample chi-square and Spearman correlation tests. Based on the inclusion and exclusion criteria, this study included 589 patients with plaques at the bifurcation of the carotid arteries. In both the acute ischemic stroke and control groups, sex, smoking, alcohol consumption, systolic blood pressure, blood sugar, cholesterol, high-density lipoprotein, and homocysteine levels were statistically significant (p < 0.05). During the Spearman correlation analysis between calcification type and acute stroke (1178 carotid arteries), different calcification types of plaques were linked with ipsilateral acute anterior circulation stroke with statistically significant differences (p＜0.001). Finally, the chi-squared test of the paired samples showed that the grade of plaque calcification is often higher on the side of acute infarction than on the side without acute infarction, and the difference is statistically significant.(p＜0.001). Carotid plaque calcification is associated with acute ischemic stroke. Our findings provide novel insights into the study of calcification in carotid atherosclerotic plaques and additional radiological evidence to clinically assess the risk of ischemic stroke.
Keywords: Atherosclerosis, carotid plaque, Calcified plaque, Stroke, computed tomography angiography
Received: 22 Dec 2024; Accepted: 27 Jan 2025.
Copyright: © 2025 Chu, Guo, Zhang, Liu and Gu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yonggang Zhang, Lianyungang Clinical Medical College, Nanjing Medical University, Lianyungang, China
Yan Gu, Lianyungang Clinical Medical College, Nanjing Medical University, Lianyungang, China
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