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REVIEW article
Front. Neurol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1549465
This article is part of the Research Topic Innovative Approaches in Glioma Therapy: Exploring New Therapeutic Frontiers View all 4 articles
Targeting Gut Microbiota: A Potential Therapeutic Approach for Tumor Microenvironment in Glioma
Provisionally accepted- 1 Shaanxi University of Chinese Medicine, Xianyang, China
- 2 Affiliated Hospital of Shaanxi University of Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang, China
Glioma, being one of the malignant tumors with the highest mortality rate globally, has an unclear pathogenesis, and the existing treatment effects still have certain limitations. The tumor microenvironment (TME) plays an important role in the occurrence, development, and recurrence of glioma. As one of the important regulatory factors of TME, the gut microbiota can regulate the progression of glioma not only by interacting with the brain through the brain-gut axis but also by influencing the tumor immune microenvironment (TIME) and inflammatory microenvironment. Recent studies have identified the gut microbiota and TME as potential therapeutic targets for glioma. This paper aims to summarize the role of the gut microbiota in TME, the association between them and glioma, and the potential of developing new intervention measures by targeting the gut microbiota. Understanding the involvement process of the gut microbiota in glioma may pave the way for the development of effective treatment methods that can regulate TME and prevent disease progression.
Keywords: Gut Microbiota, Microbiota-Brain-Gut axis, Dysbiosis, Tumor Microenvironment, Glioma
Received: 21 Dec 2024; Accepted: 03 Mar 2025.
Copyright: © 2025 Qi, Meng, Zhao, Lv, Huang, Fan and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoping Zhao, Affiliated Hospital of Shaanxi University of Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang, China
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