ORIGINAL RESEARCH article
Front. Neurol.
Sec. Sleep Disorders
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1537796
Sleep Duration and Overactive Bladder Syndrome in US Adults: A Propensity Score Matching Cohort Study Using NHANES 2005-2018
Provisionally accepted
- 1Taizhou Hospital, Wenzhou Medical University, Linhai, China
- 2Department of Traditional Chinese Medicine, Taizhou Hospital of Zhejiang Province affiliated with Wenzhou Medical University, Taizhou, China
- 3Department of Traditional Chinese Medicine, Taizhou Hospital of Zhejiang Province affiliated with Wenzhou Medical University, Linhai, Taizhou 317000, Zhejiang Province, China, Taizhou, China
- 4Department of Urology, Taizhou Cancer Hospital, Wenling, Taizhou 317502, Zhejiang Province, China, Taizhou, China
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Objective: The association between sleep duration and overactive bladder (OAB) risk remains underexplored. The aim of this study was to assess this relationship in U.S. adults using National Health and Nutrition Examination Survey (NHANES) data.Methods: This cross-sectional study included 24,360 participants aged 20-80 years with OAB wo completed the NHANES (2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018). NHANES Kidney Conditions-Urology Questionnaire data and the Overactive Bladder Symptom Score (OABSS) were collected. Sleep duration was self-reported by the participants. Propensity score matching (PSM) and multivariate logistic regression were employed to control for confounding variables, whereas a generalized additive model (GAM) was utilized to explore the nonlinear relationship between sleep duration and OAB.Results: Short sleep (<6 hours) significantly increased OAB risk (OR 1.37; 95% CI, 1.21-1.55; p < 0.01). A U-shaped relationship between sleep duration and OAB was observed, suggesting that approximately 6 hours of sleep is optimal for minimizing OAB risk. Additional risk factors for OAB included female sex, older age, higher BMI, lower education and income levels, hypertension, diabetes, and smoking. Conclusion: Both insufficient and excessive sleep durations were independently linked to increased OAB risk, and the optimal sleep duration to minimize OAB risk was approximately 6 hours. These findings emphasize the importance of targeted prevention and intervention strategies focused on sleep and other modifiable risk factors for OAB. Further research is needed to better understand the biological mechanisms linking sleep duration and OAB.
Keywords: sleep duration, overactive bladder, Cross-sectional study, NHANES, O'Kelly T
Received: 07 Jan 2025; Accepted: 24 Apr 2025.
Copyright: © 2025 wang, Jin, Hu, Huang and Mo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Licai Mo, Taizhou Hospital, Wenzhou Medical University, Linhai, China
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