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ORIGINAL RESEARCH article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1533108
Effects of Carotid plaque Crouse score and serum Hcy on the location of White Matter Hyperintensities
Provisionally accepted- The Affiliated Hospital of Qingdao University, Qingdao, China
Background and Objective: Carotid plaque Crouse score and serum homocysteine (Hcy) are closely associated with white matter hyperintensities (WMH). In recent years, it had been found that the pathological mechanism of periventricular WMH (PVWMH) and deep subcortical WMH (DSWMH) was different. In this study, we aimed to further determine the respective effects of Carotid plaque Crouse score and serum Hcy on the location of WMH. Methods: We recruited 284 patients with lacunar infarction admitted to the Affiliated Hospital of Qingdao University and conducted a retrospective cohort study. The level of serum Hcy was determined by ELISA. Carotid plaque Crouse score was evaluated by cervical vascular ultrasound. The severity of PVWMH and DSWMH was graded using a manual rating scale. Logistic regression analysis was performed to explore the relationship between Crouse score, serum Hcy and PVWMH and/or DSWMH. The critical point which Crouse score and serum Hcy played a role was determined by Quartile method. Results: After adjusting for confounding variables, Logistic regression showed that PVWMH was associated with age, hypertension, Hcy and Crouse score; DSWMH was associated with age, hypertension, and Crouse score but not with Hcy. Quartile analysis indicated that Crouse score>0.39 was associated with the occurrence of PVWMH and DSWMH, while Hcy>12.48 was only associated with the occurrence of PVWMH. Conclusion: Crouse score is associated with both PVWMH and DSWMH. High levels of Hcy is associated with the occurrence of PVWMH, but not DSWMH.White matter hypersignaling (WMH) accounts for 40% of the disease burden of cerebral small vessel diseases (CSVD) and is the most common imaging manifestation of CSVD [1]. Its manifestations are mainly high signal in T2-weighted sequence and superior or low signal in T1-weighted sequence in cranial magnetic resonance imaging (MRI) [2]. A study showed that the positively 删除[刘悦]:
Keywords: Crouse score1, Hcy2, CSVD3, WMH4, PVWMH5，DSWMH6；
Received: 23 Nov 2024; Accepted: 19 Mar 2025.
Copyright: © 2025 Liu, Tian, Cheng, Jia, Li and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shaonan Yang, The Affiliated Hospital of Qingdao University, Qingdao, China
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