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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neurorehabilitation
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1530447
This article is part of the Research Topic From bench to bedside: Inflammation in Neurovascular Disorders and Stroke View all 4 articles

Integrated Multi-Biomarker Panel of CXCL13, HS-CRP, and WBC Counts Predicts Outcomes in Stroke Neurosyphilis Patients Treated with HBO and TUS-NMES

Provisionally accepted
Wenchao He Wenchao He Shuangshuang Chen Shuangshuang Chen Ruyang Chen Ruyang Chen Jun Zhang Jun Zhang Xuehua Zhang Xuehua Zhang Minzhi Wu Minzhi Wu Dan Zhang Dan Zhang Fengfeng Zhu Fengfeng Zhu Fanghua He Fanghua He Yating Xu Yating Xu Na Lei Na Lei Wenhui Zheng Wenhui Zheng Xinyi Shan Xinyi Shan Jun Dai Jun Dai *
  • Suzhou No. 5 People’s Hospital, Soochow University Affiliated Infectious Disease Hospital, Suzhou, China

The final, formatted version of the article will be published soon.

    Background: Neurosyphilis results from Treponema pallidum invading the central nervous system, leading to severe neurological issues like stroke. Combining hyperbaric oxygen (HBO) therapy and transcranial ultrasound neuromuscular stimulation (TUS-NMES) shows promise in improving outcomes.Objective: This study evaluates the predictive value and clinical significance of CXCL13, WBC, and Hs-CRP levels in neurosyphilis patients undergoing HBO and TUS-NMES therapy.Methods: The study included 158 neurosyphilis stroke patients treated from June 2022 to January 2024. Assessments of limb motor, cognitive functions, daily living abilities, and cerebrospinal fluid biomarkers were conducted pre- and post-four weeks of combined therapy.Results: After treatment, there was a significant improvement in FMA, MoCA, and MBI scores (P<0.001). CXCL13 levels significantly decreased post-treatment, correlating with improved patient outcomes. The study found strong predictive values for CXCL13 levels in determining the efficacy of rehabilitation, with the combination of CXCL13, WBC, and Hs-CRP showing the highest predictive accuracy.Conclusion: HBO and TUS-NMES significantly enhance recovery in neurosyphilis stroke patients. CXCL13, WBC, and Hs-CRP effectively predict rehabilitation outcomes, highlighting their value in clinical management.

    Keywords: Stroke neurosyphilis, hyperbaric oxygen, Transcranial ultrasound neuromuscular stimulation, C-X-C motif chemokine ligand 13, biomarkers

    Received: 28 Nov 2024; Accepted: 28 Jan 2025.

    Copyright: © 2025 He, Chen, Chen, Zhang, Zhang, Wu, Zhang, Zhu, He, Xu, Lei, Zheng, Shan and Dai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jun Dai, Suzhou No. 5 People’s Hospital, Soochow University Affiliated Infectious Disease Hospital, Suzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.