The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neuromuscular Disorders and Peripheral Neuropathies
Volume 16 - 2025 |
doi: 10.3389/fneur.2025.1530286
Clinical study of the relationship between hepatitis B core antibody and mechanical ventilation in patients with Guillain-Barré syndrome
Provisionally accepted- 1 Department of Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China
- 2 BenQ Medical Center, Nanjing, Jiangsu Province, China
- 3 Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China
The aim of this study was to investigate the association between hepatitis B core antibody (HBcAb) positivity and the need of mechanical ventilation (MV) in patients with Guillain-Barré syndrome (GBS).We retrospectively analyzed the clinical data of 159 patients who were diagnosed with GBS between December 2014 and April 2023 in the Affiliated Hospital of Xuzhou Medical University. Patients were categorized into two groups according to the need for MV. Variables that were significantly different between the two groups in univariate analysis were analyzed through multivariate logistic regression models.The final study population included 159 patients, 28 (17.6%) of whom need MV. In univariate analysis, Medical Research council sum score (MRC) on admission (P < 0.001), bulbar paralysis (P < 0.001), autonomic dysfunction (P < 0.001), HBcAb (P = 0.009), neutrophil/lymphocyte ratio (NLR) (P < 0.001), and Serum albumin (P = 0.016) were associated with MV. Multivariate logistic regression analysis showed lower MRC on admission (OR = 0.946, 95%CI: 0.908 -0.985,
Keywords: Guillain-Barré syndrome, Hepatitis B virus, mechanical ventilation, predictors, Risk factors
Received: 18 Nov 2024; Accepted: 08 Feb 2025.
Copyright: © 2025 Zhang, Yao, Wang, Yang and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qian Yao, BenQ Medical Center, Nanjing, Jiangsu Province, China
Yuqiao Wang, Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China
Xinxin Yang, Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China
Junxiong Yin, Department of Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.