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ORIGINAL RESEARCH article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1529752
This article is part of the Research TopicReviews in Preventative Health for Stroke and Education to Stroke PreventionView all 7 articles
Joint Association of Estimated glucose disposal rate and Body Mass Index with New-Onset Stroke
Provisionally accepted- 1Tiantai People's Hospital of Zhejiang Province, Taizhou, Zhejiang Province, China
- 2The University of Chicago Medical Center, Chicago, United States
- 3Department of Neurology, Zhuji Affiliated Hospital of Wenzhou Medical University, Shaoxing, Zhejiang Province, China
- 4Beijing Hospital, Beijing, Beijing, China
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Background: Stroke is a major global health concern, and understanding its modifiable risk factors is critical for prevention. Body mass index (BMI) and estimated glucose disposal rate (eGDR), indicators of adiposity and insulin sensitivity, respectively, are independently associated with stroke risk. However, the combined effects of these factors remain underexplored.Methods: This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS), including 7,212 adults aged over 45 years. Cox proportional hazards models assessed the independent and joint associations of BMI and eGDR with new-onset stroke. Mediation analysis evaluated BMI's role in the eGDR-stroke relationship. Subgroup analyses by age, sex, and BMI categories were conducted.Results: Over a 7-year follow-up, 587 participants (8.14%) experienced new-onset stroke. Higher BMI was positively associated with stroke incidence, while lower eGDR was linked to increased stroke risk. Participants with both obesity (BMI over 28 kg/m²) and lower eGDR faced the highest stroke risk (HR: 2.63; 95% CI: 1.78-3.89). Mediation analysis revealed that BMI significantly mediated 16.78% of the association between eGDR and new-onset stroke. Subgroup analyses showed consistent associations across age, sex, and BMI categories.Conclusion: This study highlights the significant and interconnected roles of BMI and eGDR in new-onset stroke risk, with a compounding effect observed in individuals with obesity and low eGDR. Addressing both insulin resistance and adiposity through targeted interventions could effectively reduce stroke risk, particularly in high-risk populations.
Keywords: BMI, CHARLS, eGDR, Mediating effect, Stroke
Received: 17 Nov 2024; Accepted: 10 Apr 2025.
Copyright: © 2025 Yu, Shao, Lv and Xiong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yujun Xiong, Beijing Hospital, Beijing, 100730, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.