CLINICAL TRIAL article
Front. Neurol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1521112
The Effects of Leventhal's Self-Regulation Model-Based Educational Intervention on Stress, Anxiety, and Depression in Women with Multiple Sclerosis: A Randomized Educational Trial
Provisionally accepted
- 1MSc. Nursing Master's student, Student Research Committee, Arak University of Medical Sciences, Arak, Iran, Arak, Iran
- 2Ph.D in Nursing, Shazand School of Nursing, Arak University of Medical Sciences, Arak, Iran, Arak, Iran
- 3Department of Nursing, School of Nursing and Midwifery, Arak University of Medical Sciences, Arak, Iran, Arak, Iran
- 4Department of Epidemiology and Biostatistics,School of Public health ,Tehran University of Medical Sciences, Tehran, Iran, Arak, Iran
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Multiple sclerosis (MS) is a long-term, progressive neurological condition that affects the myelin sheath of nerve cells in the central nervous system. Mental health concerns are often overlooked in individuals with MS, stemming from various aspects of the illness, such as its inherent characteristics and symptoms. The present research aimed to examine the impact of Leventhal self-regulation training on stress, anxiety, and depression in MS patients.The current study was conducted as a randomized educational trial of 60 women referred to the MS Association in Arak City in 2024. The study implemented self-regulation training via the Leventhal model, which consisted of an initial face-to-face session to provide basic knowledge, eight offline sessions, and two online group sessions. The data were input into SPSS 26 software. Chi-square tests and Fisher's exact tests were utilized, independent t-tests, and Mann-Whitney's nonparametric equivalent. A repeated measures analysis of variance was conducted to assess the changes over three time points. Additionally, the Bonferroni post hoc correction was utilized. In the present study, data collection consisted of two parts: the demographic information form and the Depression Anxiety Stress Scale (DASS) questionnaire. The Iranian registry Clinical Trial code (IRCT) is IRCT20220703055351N3.
Keywords: Multiple Sclerosis, Leventhal's self-regulation, Anxiety, stress, Depression
Received: 01 Nov 2024; Accepted: 24 Apr 2025.
Copyright: © 2025 Hosseini, Shamsikhani, Jadidi and Rafie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Soheila Shamsikhani, Ph.D in Nursing, Shazand School of Nursing, Arak University of Medical Sciences, Arak, Iran, Arak, Iran
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