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ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 |
doi: 10.3389/fneur.2025.1520298
This article is part of the Research Topic Genetic Insights and Diagnostic Innovations in Cerebrovascular and Cerebrospinal Fluid Disorders View all articles
Cross-sectional study on the association between Neutrophil-Percentage-to-Albumin Ratio (NPAR) and prevalence of stroke among US adults: NHANES 1999-2018
Provisionally accepted
Chenglin Ye 1
Yong Mo 1* Tiansheng Su 1* Guangxiang Huang 1* Jiachao Lu 1* Shuling Tang 1*
Qianrong Huang 1 Qiuyun Li 1* Qian Jiang 1*
Fangzhou Guo 1 Pinghua Wu 1* Guozhong Zhang 2*
Jun Yan 1*- 1 Guangxi Medical University Cancer Hospital, Nanning, China
- 2 Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
The neutrophil-to-albumin ratio (NPAR) is a relatively novel composite biomarker of inflammation, which has been used for prognostication in cardiovascular diseases and may also be associated with stroke. A cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018, including 48,734 individuals with complete NPAR and stroke data. The association between stroke prevalence and NPAR values was assessed through multivariate regression analysis. The relationship between these variables was further visualized using restricted cubic splines (RCS). Additionally, potential factors influencing this relationship were explored through subgroup analysis. The regression model revealed a significant association between NPAR and stroke prevalence, even after adjusting for other covariates [1.06 (1.04, 1.08)]. Stroke prevalence was 62% higher in the highest NPAR group compared to the lowest [1.62 (1.40, 1.89)]. The RCS analysis further confirmed this positive correlation. Subgroup analysis showed that this association was not significantly influenced by other factors. This study establishes a strong association between NPAR and stroke prevalence. However, further studies are needed to clarify the underlying mechanisms and establish a direct causal link.
Keywords: NPAR, Stroke, NHANES, a cross-sectional study, Restricted Cubic
Received: 01 Nov 2024; Accepted: 14 Jan 2025.
Copyright: © 2025 Ye, Mo, Su, Huang, Lu, Tang, Huang, Li, Jiang, Guo, Wu, Zhang and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yong Mo, Guangxi Medical University Cancer Hospital, Nanning, China
Tiansheng Su, Guangxi Medical University Cancer Hospital, Nanning, China
Guangxiang Huang, Guangxi Medical University Cancer Hospital, Nanning, China
Jiachao Lu, Guangxi Medical University Cancer Hospital, Nanning, China
Shuling Tang, Guangxi Medical University Cancer Hospital, Nanning, China
Qiuyun Li, Guangxi Medical University Cancer Hospital, Nanning, China
Qian Jiang, Guangxi Medical University Cancer Hospital, Nanning, China
Pinghua Wu, Guangxi Medical University Cancer Hospital, Nanning, China
Guozhong Zhang, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong Province, China
Jun Yan, Guangxi Medical University Cancer Hospital, Nanning, China
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