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SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 |
doi: 10.3389/fneur.2025.1519818
The Double-Edged Sword of Statins in Intracerebral Hemorrhage Patients: A Systematic Review and Meta-Analysis
Provisionally accepted- China-Japan Union Hospital, Jilin University, Changchun, China
Background: This meta-analysis aimed to investigate the effect of statins on the prognosis of patients with intracerebral hemorrhage (ICH). Methods: We conducted a systematic search using the keywords ' statin ' and 'intracerebral hemorrhage' across four electronic databases (PubMed, Cochrane Library, Web of Science, and Embase) from their inception to October 31, 2023, to identify studies comparing the effects of statins on the prognosis of patients with ICH. The primary outcome was total mortality after ICH. This meta-analysis was registered online (PROSPERO ID: CRD42023493063). Results: Our initial search identified 5,543 studies. After applying inclusion criteria, 30 studies with a total of 42,298 patients were included in the final analysis. Our metaanalysis showed that statins significantly reduced overall mortality in patients with ICH (OR: 0.61; 95% CI: 0.51 to 0.73; I ² = 87%; P < 0.01). Subgroup analyses further demonstrated lower mortality in ICH patients treated with statins compared to those not treated, including in the propensity score matching (PSM) group (OR: 0.59; 95% CI: 0.48 to 0.74; I² = 90%; P < 0.01), the prospective cohort study (PCS) group (OR: 0.56; 95% CI: 0.40 to 0.77; I² = 89%, P < 0.01), and the retrospective cohort study (RCS) group (OR: 0.64; 95% CI: 0.51 to 0.81; I² = 87%, P < 0.01). Conclusions: Our meta-analysis of 30 studies suggests that statin use may be associated with improved mortality and functional outcomes in patients with intracerebral hemorrhage (ICH).statin therapy may improve outcomes in patients with intracerebral hemorrhage by reducing mortality and enhancing functional recovery.
Keywords: statin, intracerebral hemorrhage, Mortality, Meta-analysis, Functional prognosis
Received: 10 Nov 2024; Accepted: 08 Jan 2025.
Copyright: © 2025 Li, Xu, Wang, Yang, Shi, Wang, Xu and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
ZhongXin Xu, China-Japan Union Hospital, Jilin University, Changchun, China
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