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ORIGINAL RESEARCH article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1517760
This article is part of the Research Topic Imaging Advances in Acute Intracerebral Hemorrhage and Implications for Therapeutic Approaches View all 4 articles
Predictors of poor outcomes in patients with intracerebral hemorrhage
Provisionally accepted- 1 Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
- 2 University of Southern California, Los Angeles, California, United States
- 3 Liaocheng People's Hospital, Liaocheng, Shandong Province, China
Objective: To identify the predictors of 3-month outcomes in Chinese patients with intracerebral hemorrhage (ICH) receiving conservative management.Methods: From October 2013 to May 2016, a total of 5589 individuals with ICH were screened as part of the CRRICH study (Clinical re-evaluation of removing blood stasis therapy in treating acute intracerebral hemorrhage). Of these, 319 patients were ultimately enrolled. This study constitutes a post analysis of the CRRICH study. Potential predictors of poor outcomes following spontaneous ICH, initially identified through univariate analysis, were further evaluated using an unconditional multiple logistic regression model. Poor outcomes were defined as a modified Rankin scale score > 2 at 90 days post-ICH.Results: Of the 319 patients (mean age 62.46±0.71 years; male/female ratio 1.8:1), 89 (27.9%) had poor 3-month outcomes. Multivariable analysis showed increased odds of poor outcomes with older age (odds ratio [OR] 1.05; 95% confidence interval [CI] 1.02–1.08; P < 0.001), right hemispheric hemorrhage (OR 2.41; 95% CI 1.26–4.60; P = 0.008), intraventricular hemorrhage (OR 3.70; 95% CI 1.80–7.61; P < 0.001), and a higher National Institutes of Health Stroke Scale score (NIHSS) (OR 1.21; 95% CI 1.14–1.29; P < 0.001). Conversely, higher body mass index (BMI) (OR 0.88; 95% CI 0.77–0.99; P = 0.015) and shorter symptom-to-admission time (OR 0.77; 95% CI 0.62–0.97; P =0.025) were associated with reduced odds of poor outcomes.Conclusions: In conservatively treated ICH patients, right hemispheric involvement, ventricular hemorrhage, older age, and higher NIHSS score increased poor outcome risks at 3 months, while higher BMI and early admission reduced risks, aiding clinical prognosis prediction.
Keywords: predictors, intracerebral hemorrhage, Outcome, Body Mass Index, CRRICH trial
Received: 27 Oct 2024; Accepted: 02 Apr 2025.
Copyright: © 2025 Zeng, Zhang, Xia, Cui and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jianwen Guo, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
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