The final, formatted version of the article will be published soon.
REVIEW article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 |
doi: 10.3389/fneur.2025.1514394
This article is part of the Research Topic Exploring Immune Cell Roles in Cardiac Repair and Remodeling View all 13 articles
The Impact of Glycolysis on Ischemic Stroke: From Molecular Mechanisms to Clinical Applications
Provisionally accepted- 1 The First Clinical College of Anhui University of Chinese Medicine, Hefei, China
- 2 Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui Province, China
- 3 Graduate School, Anhui University of Chinese Medicine, Hefei, Anhui Province, China
Ischemic stroke (IS), a leading cause of disability and mortality worldwide, remains a significant challenge due to its complex pathogenesis. Glycolysis, a central metabolic pathway, plays a critical role in bridging the gap between metabolic dysfunction and neurological impairment. During ischemic conditions, glycolysis replaces oxidative phosphorylation as the primary energy source for brain tissue. However, in the ischemia-reperfusion state, neuronal cells show a particular reliance on aerobic glycolysis. Immune cells, such as monocytes, also contribute to atheromatous plaque formation and thrombi through increased aerobic glycolysis. Given glycolysis's involvement in various pathological stages of IS, it offers the potential for improved diagnosis, treatment, and prevention. This review comprehensively explores the role of glycolysis in different phases of IS, addresses existing controversies, and discusses its diagnostic and therapeutic applications. By elucidating the intricate relationship between glycolysis and IS, this review aims to provide novel insights for future research and clinical advancements.
Keywords: ischemic stroke, Glycolysis, glucose metabolism, Pathomechanism, diagnosis, Treatment
Received: 20 Oct 2024; Accepted: 10 Jan 2025.
Copyright: © 2025 Liu, Hu, Cheng, Xu and Ye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Peijia Hu, Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, 230061, Anhui Province, China
Hongliang Cheng, Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, 230061, Anhui Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.