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BRIEF RESEARCH REPORT article

Front. Neurol.
Sec. Neuromuscular Disorders and Peripheral Neuropathies
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1512357

Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials Database (PRO-ACT)

Provisionally accepted
Cecilia Quarracino Cecilia Quarracino 1Francisco Capani Francisco Capani 1,2*Matilde Otero-Losada Matilde Otero-Losada 1Gabriel Rodriguez Gabriel Rodriguez 3Santiago Perez-Lloret Santiago Perez-Lloret 4,5
  • 1 Centro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana, Buenos Aires, Argentina
  • 2 Instituto de Investigación e Innovación en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Santiago, Santiago Metropolitan Region (RM), Chile
  • 3 Clínica Enfermedades de Neurona Motora. División Neurología, Hospital General de Agudos José María Ramos Mejía, Buenos Aires, Argentina
  • 4 Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
  • 5 Instituto Universitario de Ciencias de la Salud, Fundación H.A. Barceló, Buenos Aires, Buenos Aires, Argentina

The final, formatted version of the article will be published soon.

    Purpose. To explore the frequency of orthostatic hypotension (OH) in a large sample of amyotrophic lateral sclerosis patients (ALS).From the PRO-ACT database, data of 1240 ALS patients were analyzed, focusing on blood pressure and heart rate before and after standing. OH was defined as a drop in systolic/diastolic blood pressure > 20/10 mm Hg within 3 minutes of standing. Neurogenic OH was diagnosed when the heart rate increase was below 15 beats per minute in patients not taking medications that could affect this response.Results. At baseline, 138 (11.1%) patients showed OH, 76.1% of whom had neurogenic OH. At follow-up, 163 patients (13.1%) had OH, 71.2% with neurogenic OH. Only 22.5% of the patients with OH at baseline had OH at follow-up.In a large sample of ALS patients, OH occurred in 11%-13%, pointing to a subgroup that might require special care to avoid related complications.

    Keywords: ALS dysautonomia, cardiac dysautonomia, orthostatic hypotension, sympathetic cardiac dysautonomia, Amiotrofic lateral sclerosis

    Received: 16 Oct 2024; Accepted: 03 Jan 2025.

    Copyright: © 2025 Quarracino, Capani, Otero-Losada, Rodriguez and Perez-Lloret. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Francisco Capani, Centro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana, Buenos Aires, Argentina

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.