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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1510235

Predicting Prognosis Using Stroke-Heart Indicator: Brain Natriuretic Peptide in Patients with Aneurysmal Subarachnoid Hemorrhage

Provisionally accepted
Jionghao Xue Jionghao Xue 1*FA LIN FA LIN 1Minghao Liu Minghao Liu 1*Wenxiong Song Wenxiong Song 1*Runting Li Runting Li 1Yu Chen Yu Chen 1Jun Yang Jun Yang 1Heze Han Heze Han 1*Yitong Jia Yitong Jia 1*XiaoLin Chen XiaoLin Chen 1*Rong Wang Rong Wang 1*Yuanli Zhao Yuanli Zhao 2*
  • 1 Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing Municipality, China
  • 2 Peking Union Medical College Hospital (CAMS), Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Objective: This study aims to explore the correlation between brain natriuretic peptide (BNP) levels and prognosis in patients suffering from aneurysmal subarachnoid hemorrhage (aSAH).Methods: This retrospective study included patients diagnosed with aneurysmal subarachnoid hemorrhage (aSAH) at Beijing Tiantan Hospital between January 2015 and September 2021. Plasma BNP levels were measured upon admission and log-transformed to reduce skewness. Elevated BNP was defined as lgBNP ≥ 1.79 (equivalent to BNP ≥62 pg/mL). The primary outcome was poor prognosis, defined as a modified Rankin Scale (mRS) score ≥3 at 90 days. Univariable and multivariable logistic regression analyses were conducted to examine the association between BNP levels and prognosis. Additionally, we assessed the potential impact of incorporating BNP into a predictive model for poor prognosis Results: The statistical analysis encompassed a total of 932 patients. Among them, 171 individuals experienced unfavorable prognosis (mRS ≥3) during follow-up, and 444 patients had elevated BNP levels, defined as lgBNP ≥ 1.79. After accounting for confounding factors, elevated BNP levels remained a significant independent risk factor of a poor prognosis (p=0.047, OR= 1.49, 95%CI= 1.01-2.20). Nevertheless, BNP's predictive value alone might not warrant its inclusion in a prognostic model. Conclusion: Elevated BNP levels independently forecast unfavorable prognosis in patients with aSAH, even though the cutoff value is lower than the cardiology standards. Continuous monitoring and personalized hospitalization plans can be vital for these patients.

    Keywords: stroke heart disease, ASAH, bnp, Retrospective Studies, Risk factors

    Received: 12 Oct 2024; Accepted: 10 Jan 2025.

    Copyright: © 2025 Xue, LIN, Liu, Song, Li, Chen, Yang, Han, Jia, Chen, Wang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jionghao Xue, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, Beijing Municipality, China
    Minghao Liu, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, Beijing Municipality, China
    Wenxiong Song, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, Beijing Municipality, China
    Heze Han, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, Beijing Municipality, China
    Yitong Jia, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, Beijing Municipality, China
    XiaoLin Chen, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, Beijing Municipality, China
    Rong Wang, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, Beijing Municipality, China
    Yuanli Zhao, Peking Union Medical College Hospital (CAMS), Beijing, 100730, Beijing Municipality, China

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