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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Sleep Disorders
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1510222
This article is part of the Research Topic Beyond Rest: Exploring the Bidirectional Relationship and Intersecting Pathways of Sleep and Physical Health View all 8 articles

Impact of sleep chronotype on blood pressure and metabolic markers

Provisionally accepted
Weiwei Huang Weiwei Huang 1Qinglu Wang Qinglu Wang 2Yuan Gao Yuan Gao 3Jiefeng Wang Jiefeng Wang 4Feihao Wang Feihao Wang 5Jiyou Tang Jiyou Tang 1*
  • 1 Shandong Provincial Qianfoshan Hospital, Jinan, China
  • 2 The Second People Hospital of Dezhou, Dezhou, Shandong, China
  • 3 The Second Affiliated Hospital of Shandong First Medical University, Tai’an, Shandong Province, China
  • 4 Tengzhou City Center People's Hospital, Zaozhuang, Shandong Province, China
  • 5 Liaocheng People's Hospital, Liaocheng, Shandong Province, China

The final, formatted version of the article will be published soon.

    Objective The aim of this study was to investigate the correlation between sleep chronotype and metabolic markers to further reveal the influence of sleep chronotype on human health.The Morningness-Eveningness Questionnaire was administered to 442 volunteers aged 23-70 years old. The sleep chronotype was divided into morning type (167 cases), neither type (224 cases), and evening type (51 cases). Blood pressure was recorded, and fasting venous blood samples were collected to assess liver function, renal function, blood glucose levels, blood lipid profile, and other biochemical parameters.Results 1. There was a statistically significant difference in the age of the morning type, neither type, and evening type (p<0.01), but there was no significant difference in gender, height, weight, and BMI (ps>0.05). 2. After controlling for the influence of age-related factors, significant differences were seen between morning type, neither type, and evening type groups in creatinine and aspartate aminotransferase (p<0.05). 3. After controlling for the influence of age-related factors, the evening type group had lower systolic blood pressure, diastolic pressure, and mean arterial pressure (MAP) compared to the morning type and neither type (p<0.05). 4.After controlling the influence of age-related factors, the MEQ scores were positively correlated with systolic blood pressure, diastolic blood pressure, and mean arterial pressure (r=0.099 、 0.096、0.104, ps<0.05).The evening sleep type is more prone to daytime sleepiness. There were significant differences observed in systolic blood pressure, diastolic blood pressure, and MAP. These variations may be linked to the effects of different sleep chronotype on blood pressure regulation or the blood pressure's autonomous rhythm.

    Keywords: Sleep chronotype, metabolic markers, Morningness-Eveningness Questionnaire, Blood Pressure, Creatinine, aspartate aminotransferase

    Received: 12 Oct 2024; Accepted: 31 Jan 2025.

    Copyright: © 2025 Huang, Wang, Gao, Wang, Wang and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiyou Tang, Shandong Provincial Qianfoshan Hospital, Jinan, China

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