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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1500572
This article is part of the Research Topic Screening Remnant Lipid Markers in Cardiometabolic Diseases View all 7 articles

Analyzing the correlation between acute ischemic stroke and triglyceride-glucose index based on ordered logistic regression

Provisionally accepted
Liu He Liu He Rong Li Rong Li Lei Wang Lei Wang Xi Zhu Xi Zhu Qiang Zhou Qiang Zhou Zhiyong Yang Zhiyong Yang Hua Liu Hua Liu *
  • The Third People's Hospital of Chengdu , The Affiliated Hospital of Southwest Jiao Tong University, Chengdu, China

The final, formatted version of the article will be published soon.

    Objective: To investigate the association between insulin resistance, measured by the triglyceride-glucose (TyG) index, and clinical outcomes in patients with acute ischemic stroke who underwent intravenous thrombolysis with alteplase.Methods: This retrospective study included 165 patients with acute ischemic stroke treated with intravenous alteplase. Insulin resistance was evaluated using the TyG index, and its relationship with the modified Rankin Scale (mRS) scores was analyzed. The analysis was conducted using R software (version R 4.1.3) to evaluate the correlation between the TyG index and functional outcomes at 14, 30, and 90 days post-stroke.The study found that each unit increase in the TyG index significantly raised the risk of poor functional outcomes at 14 days (OR 9.86; 95% CI: 3.32-32.21; P < 0.001), 30 days (OR 5.82; 95% CI: 2.08-17.45; P = 0.001), and 90 days (OR 9.79; 95% CI: 3.33-31.66; P < 0.001) following a stroke. Higher TyG index values were associated with worse neurological outcomes. Although male gender, older age, and smoking were also linked to poorer outcomes, these associations did not reach statistical significance.The findings suggest that a higher TyG index, indicating greater insulin resistance, is associated with worse neurological outcomes in stroke patients. Early intervention targeting insulin resistance may improve clinical outcomes in ischemic stroke patients, and further research is needed to explore additional factors affecting neurological recovery.

    Keywords: Acute ischemic stroke, Triglyceride-glucose index, Insulin Resistance, intravenous thrombolysis, Modified Rankin scale

    Received: 08 Oct 2024; Accepted: 15 Jan 2025.

    Copyright: © 2025 He, Li, Wang, Zhu, Zhou, Yang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hua Liu, The Third People's Hospital of Chengdu , The Affiliated Hospital of Southwest Jiao Tong University, Chengdu, China

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