Role of microRNA in the risk stratification of Ischemic Strokes

Hosam Al-Jehani ^1* Ahmed Hafez Mousa ¹ May Adel Alhamid ² Fawaz Al-Mufti ³

• ¹ Department of Neurosurgery and Interventional Neuroradiology, Imam Abdulrahman Bin Faisal University, Al-Khobar, Kingdom of Saudi Arabia, King Fahad Specialist Hospital Dammam, Dammam, Saudi Arabia
• ² Department of Neurology and Interventional Neuroradiology, Imam Abdulrahman Bin Faisal University, Al-Khobar, Kingdom of Saudi Arabia, King Fahad Specialist Hospital Dammam, Dammam, Saudi Arabia
• ³ Department of Neurology and Neurosurgery, Westchester Medical Center, Valhalla, New York, United States

Background: Ischemic stroke is a major cause of death and morbidity, and risk classification is essential for predicting therapeutic outcomes. MicroRNAs may be useful indicators for risk stratification, as they control gene expression and influence physiological and pathological processes.Methodology: A systematic strategy was developed to search relevant material using databases like PubMed, Scopus, and Web of Science. Selection criteria included human research, a certain date, or categories of studies. Data extraction, synthesis, and analysis were carried out to find trends, similarities, and differences among the chosen studies. The study's design, sample size, methodology, statistical analysis, and any potential biases or restrictions from the selected reference papers were also taken into account.MicroRNA is an important biomarker for risk stratification in Ischemic Strokes. It can be used to identify Stroke-Specific microRNA Signatures, identify diagnostic and prognostic values, and regulate Vascular Inflammation, Endothelial Dysfunction, and Thrombus Formation and Resolution. It also has potential therapeutic applications.MicroRNAs have emerged as promising biomarkers for predicting stroke risk, severity of strokes, and clinical outcomes. They can be used to predict the severity of a stroke and aid clinicians in making treatment decisions.