AUTHOR=Zhao Haonan , Lu Sikai , Jie Yang , Chao Wu , Zhu Wenxia , Huang Dongya TITLE=Comprehensive analysis of the ischemic stroke burden at global, regional, and national levels (1990–2021): trends, influencing factors, and future projections JOURNAL=Frontiers in Neurology VOLUME=16 YEAR=2025 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1492691 DOI=10.3389/fneur.2025.1492691 ISSN=1664-2295