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REVIEW article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1483842
Roles of Neuroimaging Markers and Biomarkers in Cerebral Small Vessel
Provisionally accepted- The Affiliated Hospital of Qingdao University, Qingdao, China
Abstract：Cerebral small vessel disease (CSVD) is an intracranial vascular disorders caused by impairment of cerebral microvessels, with various pathological backgrounds [1]. At present, a clear and definitive set of diagnostic criteria for CSVD continues to be elusive, its diagnosis primarily relies on medical history, clinical presentation, brain imaging features and genetic detection. In clinical practice, no single biomarker was identified. Previous studies have delved into various biomarkers in CSVD and their relationships with cognitive functions, yielding promising candidates [2]. However, drawing a unified and conclusive consensus poses a challenge due to the inherent heterogeneity in research. Therefore, we reviewed the current progression of CSVD biomarkers and the relationship to cognitive functions, mainly including neuroimaging markers, biomarkers related to cerebrospinal fluid (CSF), as well as blood to assist clinicians to diagnose.
Keywords: Cerebral small vessel disease, neuroimaging markers, cerebrospinal fluid biomarkers, blood biomarkers, cognitive functions
Received: 20 Aug 2024; Accepted: 05 Mar 2025.
Copyright: © 2025 Song, Jin, Luan and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xueping Zheng, The Affiliated Hospital of Qingdao University, Qingdao, China
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