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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1478175

A Multicenter Analysis to Identify the Risk Factors for Stroke Recurrence and Mortality Within One Year

Provisionally accepted
Eman A. Alraddadi Eman A. Alraddadi 1Hashim F. Alotaibi Hashim F. Alotaibi 1Yasser Alatawi Yasser Alatawi 2Ahmed Aljabri Ahmed Aljabri 1Ahmed A. Alghamdi Ahmed A. Alghamdi 1Fahad Alturki Fahad Alturki 1Faisal F. Alamri Faisal F. Alamri 1*
  • 1 College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia
  • 2 University of Tabuk, Tabuk, Tabuk, Saudi Arabia

The final, formatted version of the article will be published soon.

    Stroke recurrence is a serious and prevalent complication of ischemic stroke that warrants additional investigation.A hospital-based retrospective observational study included acute-subacute ischemic stroke adult patients. The primary aim was to determine the risk factors associated with recurrent stroke within 365 days. Additionally, a combined outcome consisting of any stroke recurrence or all-cause mortality within 365 days was considered a secondary outcome. Univariate and multivariable Cox proportional-hazards models were used to examine the association of risk factors with stroke recurrence and composite death/stroke recurrence.Of 1244 patients, 112 (9%) experienced stroke recurrence. The multivariable analysis identified risk factors for stroke recurrence including a history of previous stroke (HR=3.65, 95% CI:2.28-5.99, p=0.0001), tissue plasminogen activator (tPA) treatment

    Keywords: Stroke recurrence, Mortality, ischemic stroke, Risk factors, stroke complication

    Received: 12 Aug 2024; Accepted: 15 Jan 2025.

    Copyright: © 2025 Alraddadi, Alotaibi, Alatawi, Aljabri, Alghamdi, Alturki and Alamri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Faisal F. Alamri, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia

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