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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1465559
This article is part of the Research Topic Advances and controversies in ischemic stroke management: from prevention to diagnosis and acute treatment View all 95 articles

Inflammation and endothelial gene polymorphism are associated with ischemic stroke

Provisionally accepted
Wanli Chen Wanli Chen 1Jie Li Jie Li 1Jintao Zhou Jintao Zhou 2Xingyang Yi Xingyang Yi 1*Hong Chen Hong Chen 1*
  • 1 People’s Hospital of Deyang City, Deyang, China
  • 2 Yongzhou Central Hospital, Yongzhou, Hunan, China

The final, formatted version of the article will be published soon.

    Aim: Evaluate the correlation between ischemic stroke and genetic variations related to inflammation and endothelial function.Methods: This was a multicenter cross-sectional research conducted in southwestern China.Residents aged≥40 years voluntarily join in the face-to-face survey in 8 communities. 2377 participants were at high risk of stroke, of which 429 had a previous history of ischemic stroke. We selected the 429 ischemic stroke patients as the research subjects, and adopted a 1:1 matching method to select 429 healthy people with a 2-year age difference and the same gender and hypertension as the control group. We detected genotypes of 19 variants in 10 genes related to inflammation and endothelial function. Analyze gene-gene interaction through generalized multifactor dimensionality reduction (GMDR).Results: Analysis found no statistically significant differences in age, gender, hypertension, BMI, and smoking history between ischemic stroke patients and healthy control group. Compared with the healthy group, ischemic stroke group has a higher proportion of diabetes, heart disease, dyslipidemia, stroke family history, and a higher proportion of lack of exercise. HABP2 rs7923349, NOS2A rs8081248, HABP2 rs932650 were related to stroke in univariate analysis. GMDR analysis showed significant gene-gene interactions between HABP2 rs7923349,HABP2 rs932650. After adjusting for covariates, high-risk interaction genotypes between these two variants were independently associated with higher stroke risk (OR, 3.578, 95% CI: 2.618-4.890, P < 0.001). Conclusion: This study found that specific variations in genes related to inflammation and endothelial function are associated with ischemic stroke. The high-risk interactive genotypes among HABP2 rs7923349, HABP2 rs932650 distinctly increased the risk of ischemic stroke.

    Keywords: Stroke, High-risk stroke population, Genetic polymorphism, Inflammation, Endothelial Function

    Received: 16 Jul 2024; Accepted: 23 Jan 2025.

    Copyright: © 2025 Chen, Li, Zhou, Yi and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xingyang Yi, People’s Hospital of Deyang City, Deyang, China
    Hong Chen, People’s Hospital of Deyang City, Deyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.