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ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1465508
Predictive Value of Fibrinogen to Albumin Ratio for Hemorrhagic Transformation Following Intravenous Thrombolysis in Ischemic Stroke:A Retrospective Propensity-Matched Score Analysis
Provisionally accepted- First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China
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Objective: This study aims to explore the factors associated with the hemorrhagic transformation (HT) in acute ischemic stroke patients after intravenous thrombolysis, with particular focus on the relationship with post-thrombolysis fibrinogen-albumin ratio (FAR).Methods: The clinical record of 569 acute ischemic stroke (AIS) patients admitted to our department from 2020 to 2023 were retrospectively analyzed. All eligible patients were stratified into HT and Non-HT (NHT) groups. Propensity score (PS) matching was performed between both groups.Receiver Operating Characteristic (ROC) curves were employed to assess the predictive performance of FAR, determining the optimal predictive value.Results: Ultimately, 142 patients were included, with 71 in the HT group and 71 in the NHT group.After propensity score matching, there was a significant association between FAR and HT (OR=1.40, 95 % CI, 1.187-1.645; P ＜0.001). The ROC curve analysis indicated FAR predicts HT after intravenous thrombolysis with an AUC of 0.751 (95 % CI, 0.669-0.831; P ＜0.001) and an optimal cut-off value of 0.0918. The corresponding sensitivity and specificity were 78.9 % and 60.9 %, respectively. Conclusion: In ischemic stroke patients undergoing IVT, FAR may serve as a promising biochemical marker for predicting HT in AIS patients after IVT.
Keywords: ischemic stroke, intravenous thrombolysis, Hemorrhagic transformation, Fibrinogen, albumin
Received: 16 Jul 2024; Accepted: 16 Apr 2025.
Copyright: © 2025 Liu, jia and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Gang Wang, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China
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