Skip to main content

ORIGINAL RESEARCH article

Front. Neurol.
Sec. Endovascular and Interventional Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1462108

Analysis of the safety and efficacy of flow diverter device in the treatment of tandem aneurysms in the internal carotid artery

Provisionally accepted
Jun Wan Jun Wan 1,2Ligang Xu Ligang Xu 2Yeqing Jiang Yeqing Jiang 3Lei Zhang Lei Zhang 2Zhenyu Wang Zhenyu Wang 2Shengzhang Wang Shengzhang Wang 1*Xiaolong Zhang Xiaolong Zhang 3*
  • 1 Department of Aeronautics and Astronautics, Fudan University, Shanghai, China
  • 2 Shanghai Jing'an District Central Hospital, Jingan Qu, Shanghai, China
  • 3 Huashan Hospital, Fudan University, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    To investigate the clinical efficacy and safety of flow diverter device in the treatment of tandem aneurysms in the internal carotid artery.: This study was a retrospectively observational study involving two neurointerventional centers. Sixteen Patients with tandem aneurysms in the internal carotid artery treated with FDD and Digital Subtraction Angiography follow-up in Huashan Hospital Affiliated with Fudan University and Jing'an District Central Hospital Affiliated with Fudan University from 2020.08 to 2023.12 were included. The outcomes included the angiographic occlusion rate of aneurysms, complications, and the modified Rankin Scale score. The risk factors of complete occlusion of tandem aneurysms were explored by logistic regression analysis. A total of 38 aneurysms were included, including 21 aneurysms of 8 patients in the Pipeline Embolization Device group and 17 aneurysms of 8 patients in the Tubridge Flow Diverter group.A total of 16 FDD stents were implanted, 8in each PED and TFD group, with a technical success rate of 100%. The median value of maximum aneurysm diameter was 4.27(3.57-5.41) mm. Among them, 28 aneurysms had a maximum diameter of < 5 mm (73.7%), 10 aneurysms had a maximum diameter of 5-15 mm (26.3%). All patients were followed up clinically for a median of 25.5 months (15.5-28.7 months). There were no deaths and symptomatic complications. The modified Rankin Scale scores of 16 patients were all less than 2. All patients were examined by angiography with a median of 14 months (6-27 months). Among them, there were 5 Consensus Grading Scale for Endovascular Aneurysm Occlusion (CGSFEAO) grade 5 (13.2 %), 1 CGSFEAO grade 4 (2.6%), 1 CGSFEAO grade 2 (2.6%) and 31 CGSFEAO grade 0 (81.6 %). The complete occlusion rate of intracranial aneurysm in the whole study was 81.6%, including 85.7% in the PED group and 76.5% in the TFD group, and there was no significant statistical difference between the two groups. Statistically significant variables were not found in univariate logistic regression analysis.FDD is safe and effective in treating tandem aneurysms in the internal carotid artery with a high occlusion rate and few complications. TFD is comparable to PED in the treatment of intracranial tandem aneurysms.

    Keywords: Intracranial aneurysms, Tandem aneurysms, Flow diverter device, pipeline, Tubridge

    Received: 09 Jul 2024; Accepted: 03 Jan 2025.

    Copyright: © 2025 Wan, Xu, Jiang, Zhang, Wang, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shengzhang Wang, Department of Aeronautics and Astronautics, Fudan University, Shanghai, China
    Xiaolong Zhang, Huashan Hospital, Fudan University, Shanghai, Shanghai Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.