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ORIGINAL RESEARCH article

Front. Neurol.

Sec. Endovascular and Interventional Neurology

Volume 16 - 2025 | doi: 10.3389/fneur.2025.1453841

This article is part of the Research Topic Intracranial aneurysms, AVM and other vascular malformations, and connective tissue disorders as potential causes of stroke: Advances in diagnosis and therapeutics including novel neurosurgical techniques View all 15 articles

Endovascular Recanalization of Symptomatic Chronic Cerebral Artery Occlusion: Predictors for Successful Recanalization and Perioperative Complications

Provisionally accepted
Xueqian Zhang Xueqian Zhang 1,2Yang Li Yang Li 3Kuochang Yin Kuochang Yin 2Zhiwei Hao Zhiwei Hao 4Yidian Fu Yidian Fu 1Qishuo Yang Qishuo Yang 4Guodong Xu Guodong Xu 2Peiyuan Lv Peiyuan Lv 1,2*
  • 1 Hebei Medical University, Shijiazhuang, Hebei Province, China
  • 2 Hebei General Hospital, Shijiazhuang, China
  • 3 Hebei Normal University, Shijiazhuang, Hebei Province, China
  • 4 Hebei North University, Zhangjiakou, Hebei Province, China

The final, formatted version of the article will be published soon.

    ABSTRACTBACKGROUND AND PURPOSE Endovascular recanalization and stenting has been used to treat patients with symptomatic chronic cerebral artery occlusion,including intracranial vertebrobasilar artery occlusion and internal carotid artery occlusion.Our challenge is to improve success rates and reduce the incidence of postoperative complications.This study sought to identify potential predictors for successful recanalization.METHODS Our study included 103 consecutive patients between February 2021 and October 2024 with symptomatic chronic cerebral artery occlusion who were treated with endovascular recanalization. We recorded clinical information, laboratory and examination results, radiologic characteristics and procedural results of patients. Factors affecting surgical outcomes were analyzed by univariate and multivariate analyses.RESULTS A total of 103 consecutive CCAO recanalization attempts were performed from February 2021 to October 2024 in 103 patients (78 men; age 61.1±11.1 years; range: 32 to 81 years) with overall technical success rate 68.9%. Patients had chronic comorbidities such as hypertension (78,75.7%), diabetes mellitus (32,31.10%), and cardiac disease (12,11.7%). 38(36.9%) had a history of smoking,and 23(22.3%) had a history of drinking.The rate of overall intraoperative complication was 10.7% (11/103).Multivariate analysis showed that stump morphology, smoking history, duration from last neurologic event(Longer than six months or not), age, NLR were significantly associated with successful recanalization. According to the coefficients of the prediction model, the technical success rates were 100%, 66.7% and 11.1% in patients with ≤6,6-10,≥10 points, respectively.CONCLUSIONS The morphology of occluded stumps,duration from last neurologic event,age,smoking history and NLR can be used to predict the outcome of vascular recanalization.KEYWORDS Chronic Cerebral Artery Occlusion, CCAO; Endovascular Treatment, ET; Chronically occluded internal carotid artery, COICA; Basilar artery occlusion, BAO; NLR, Neutrophil-to-lymphocyte ratio.

    Keywords: Chronic Cerebral Artery Occlusion, CCAO, Endovascular Treatment, ET, Chronically occluded internal carotid artery, COICA, Basilar artery occlusion, BAO, NLR, Neutrophil-to-lymphocyte ratio Chronic Cerebral Artery Occlusion, CCAO, NLR, neutrophil-to-lymphocyte ratio

    Received: 23 Jul 2024; Accepted: 21 Mar 2025.

    Copyright: © 2025 Zhang, Li, Yin, Hao, Fu, Yang, Xu and Lv. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Peiyuan Lv, Hebei General Hospital, Shijiazhuang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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