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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neuro-Otology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1444928
This article is part of the Research Topic Meniere’s Disease: From Diagnosis to Treatment View all 5 articles

The Impact of Endolymphatic Hydrops on Wideband Acoustic Immittance and Otoacoustic Emissions in Guinea Pigs

Provisionally accepted
Huan Lin Huan Lin 1Xuanyi Li Xuanyi Li 2Huiying Zhang Huiying Zhang 3*Yi Mu Yi Mu 3*Xi Wang Xi Wang 3*Naveena Konduru Naveena Konduru 3*Renlong Ji Renlong Ji 3*Wen Liu Wen Liu 1,2,3*Fei Zhao Fei Zhao 4Wen Jiang Wen Jiang 1,2,3*Yuehua Qiao Yuehua Qiao 1,2,3*
  • 1 Jiangsu Auditory Engineering Research Center, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China
  • 2 Department of ENT, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China
  • 3 Xuzhou Medical University, Xuzhou, Jiangsu Province, China
  • 4 School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, Wales, United Kingdom

The final, formatted version of the article will be published soon.

    Background: Inner ear disorders, such as EH, commonly lead to hearing loss and vestibular dysfunction. EH is particularly prevalent in various inner ear diseases, including Meniere's disease. We aimed to evaluate the effects of EH on WAI and OAEs. Objective: This study explores the potential of wideband acoustic immittance (WAI) and Otoacoustic Emissions (OAEs) for the early detection of changes in acoustic transmission associated with vasopressin-induced endolymphatic hydrops (EH) in a guinea pig model. Methods: We induced EH in guinea pigs via daily intraperitoneal injections of arginine vasopressin over 14 consecutive days. Auditory function was assessed using Auditory Brainstem Responses (ABR), while changes in sound energy transmission were measured using WAI and Distortion Products Otoacoustic Emissions (DPOAE). Results: Increased ABR thresholds in EH models were statistically significant (p < 0.05). After 14 days of EH induction, absorbance at 1 kHz significantly increased, whereas it significantly decreased at 4 kHz and 6 kHz (p < 0.05). DPOAE measures, both magnitude and phase, showed no significant changes (p > 0.05). Conclusion: WAI demonstrates greater sensitivity than DPOAE in the early detection of acoustic transmission alterations in EH models, suggesting its utility as a diagnostic tool in early-stage inner ear disorders.

    Keywords: Wideband acoustic immittance, Endolymphatic Hydrops, ABR, DPOAE, Guinea Pigs

    Received: 06 Jun 2024; Accepted: 08 Jan 2025.

    Copyright: © 2025 Lin, Li, Zhang, Mu, Wang, Konduru, Ji, Liu, Zhao, Jiang and Qiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Huiying Zhang, Xuzhou Medical University, Xuzhou, 221004, Jiangsu Province, China
    Yi Mu, Xuzhou Medical University, Xuzhou, 221004, Jiangsu Province, China
    Xi Wang, Xuzhou Medical University, Xuzhou, 221004, Jiangsu Province, China
    Naveena Konduru, Xuzhou Medical University, Xuzhou, 221004, Jiangsu Province, China
    Renlong Ji, Xuzhou Medical University, Xuzhou, 221004, Jiangsu Province, China
    Wen Liu, Department of ENT, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China
    Wen Jiang, Xuzhou Medical University, Xuzhou, 221004, Jiangsu Province, China
    Yuehua Qiao, Xuzhou Medical University, Xuzhou, 221004, Jiangsu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.