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MINI REVIEW article
Front. Neurol.
Sec. Neurogenetics
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1422707
This article is part of the Research Topic Reviews in Neurogenetics View all 3 articles
Decoding the Genetic Blueprints of Neurological Disorders: Disease Mechanisms and Breakthrough Gene Therapies
Provisionally accepted
Umar Saeed 1,2*
ZAHRA ZAHID PIRACHA 2
Muhammad Nouman Tariq 3 Shayan Syed 3 Maria Rauf 4 Laiba Razaq 3 Muhammad Kaleem Iftikhar 5 Amna Maqsood 3 Syed Muhammad Ahsan 6 Elyeen Noor 2 Seneen Noor 2- 1 Ajou University, Suweon, Republic of Korea
- 2 International Center of Medical Sciences Research (ICMSR), Islamabad, Islamabad, Pakistan
- 3 Akhtar Saeed Medical and Dental College, Lahore, Punjab, Pakistan
- 4 University College of Medicine and Dentistry, University of Lahore, Lahore, Punjab, Pakistan
- 5 Punjab Institute of Neurosciences (PINS), Lahore, Punjab, Pakistan
- 6 Dow University of Health Sciences, Karachi, Punjab, Pakistan
Neurological disorders pose a rapidly growing global health burden, significantly affecting cognitive and motor functions with profound societal repercussions. This comprehensive review probe into the genetic foundations of various neurological conditions while exploring innovative RNA-based therapeutics particularly gene therapies as cutting edge treatment strategies. Through an in-depth analysis of existing literature, the study examines the genetic landscape, disease mechanisms, and gene-based intervention possibilities across a range of neurological disorders, including Cerebellar
Keywords: ataxias, Autosomal recessive ataxia, Mitochondrial Cerebellar Ataxia, Multiple system atrophy (MSA), Idiopathic late-onset cerebellar ataxia, Hereditary spastic paraplegias, Alzheimer's disease, Vascular Dementia
Received: 24 Apr 2024; Accepted: 13 Feb 2025.
Copyright: © 2025 Saeed, PIRACHA, Tariq, Syed, Rauf, Razaq, Kaleem Iftikhar, Maqsood, Ahsan, Noor and Noor. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Umar Saeed, Ajou University, Suweon, Republic of Korea
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