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REVIEW article

Front. Neurol.
Sec. Neuro-Ophthalmology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1526973

Unlocking the Potential for Optic Nerve Regeneration Over Long Distances: A Multi-Therapeutic Intervention

Provisionally accepted
Zhen-Gang Liu Zhen-Gang Liu 1LaiYang Zhou LaiYang Zhou 2Yong-Quan Sun Yong-Quan Sun 2yihang ma yihang ma 1Chang-Mei Liu Chang-Mei Liu 2BOYIN ZHANG BOYIN ZHANG 1*
  • 1 Jilin University, Changchun, China
  • 2 Research Center for Stem Cell and Regenerative Medicine, Institute of Zoology, Chinese Academy of Sciences (CAS), Beijing, China

The final, formatted version of the article will be published soon.

    Retinal ganglion cells (RGCs) generally fail to regenerate axons, resulting in irreversible vision loss after optic nerve injury. While many studies have shown that modulating specific genes can enhance RGCs survival and promote optic nerve regeneration, inducing long-distance axon regeneration in vivo through single-gene manipulation remains challenging. Nevertheless, combined multi-gene therapies have proven effective in significantly enhancing axonal regeneration. At present, research on promoting optic nerve regeneration remains slow, with most studies unable to achieve axonal growth beyond the optic chiasm or reestablish connections with the brain. Future research priorities include directing axonal growth along correct pathways, facilitating synapse formation and myelination, and modifying the inhibitory microenvironment. These strategies are crucial not only for optic nerve regeneration but also for broader applications in central nervous system repair.In this review, we discuss multifactors therapeutic strategies for optic nerve regeneration, offering insights into advancing nerve regeneration research.

    Keywords: Optic Nerve, axon regeneration, Retinal Ganglion Cells, immune microenvironment, Multiple genes

    Received: 15 Nov 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Liu, Zhou, Sun, ma, Liu and ZHANG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: BOYIN ZHANG, Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.