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STUDY PROTOCOL article

Front. Neurol.
Sec. Neurorehabilitation
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1519513
This article is part of the Research Topic Cognitive Strategies in motor learning and Rehabilitation View all 5 articles

Effectiveness and safety of traditional Chinese therapies intreating patients with Amyotrophic Lateral Sclerosis: A protocol for systematic review and meta-analysis

Provisionally accepted
Rui Li Rui Li 1*Tingting Bao Tingting Bao 2*Bei Li Bei Li 3peng Xia peng Xia 2*tingting Zhang tingting Zhang 2*Haoli Zhang Haoli Zhang 4*Fei Huang Fei Huang 2*
  • 1 Huangpi District Traditional Chinese Medicine Hospital, Wuhan, Hebei Province, China
  • 2 Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei Province, China
  • 3 Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
  • 4 Hubei Minzu University, Enshi, China

The final, formatted version of the article will be published soon.

    Background: Amyotrophic lateral sclerosis (ALS) is a chronic, progressive disease that affects both upper and lower motor neurons. Some physicians have used traditional Chinese therapies(TCT) to treat ALS. However, there has been no systematic review or meta-analysis to evaluate the effectiveness and safety of TCT interventions. This review aims to analyze the effects of TCT interventions for patients with amyotrophic lateral sclerosis. Methods and analysis: This study will include randomized, non-randomized, and quasi-experimental clinical trials, with participants being any age Amyotrophic Lateral Sclerosis (ALS) patients who have undergone TCT treatment. Two researchers will independently search databases including CENTRAL, PubMed, PEDro, EMBASE, CNKI, CBM, and SPORTDiscus, without restrictions on language or publication date. These researchers will independently screen titles and abstracts and extract data from the included studies. If deemed suitable for meta-analysis, data synthesis will be conducted using Review Manager V.5.3 software; any discrepancies will be resolved by a third researcher. The meta-analysis will compare the effects of TCT with placebo or other interventions. The main endpoint evaluated was the decrease in the overall score of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R; scoring from 0 to 48, where higher scores denote greater functionality) over a period of 24 weeks. Additional endpoints included the reduction rates in isometric muscle power, levels of phosphorylated axonal neurofilament H subunits in plasma, and slow vital capacity measurements. F

    Keywords: Traditional Chinese therapies, Amyotrophic Lateral Sclerosis, protocol, ALS, Meta - analysis

    Received: 30 Oct 2024; Accepted: 10 Dec 2024.

    Copyright: © 2024 Li, Bao, Li, Xia, Zhang, Zhang and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Rui Li, Huangpi District Traditional Chinese Medicine Hospital, Wuhan, Hebei Province, China
    Tingting Bao, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061, Hubei Province, China
    peng Xia, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061, Hubei Province, China
    tingting Zhang, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061, Hubei Province, China
    Haoli Zhang, Hubei Minzu University, Enshi, China
    Fei Huang, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061, Hubei Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.